2021
1. Takahashi, H.,* Caputo, G.A. and Kuroda, K. (2021) Amphiphilic Polymer therapeutics: An alternative platform in the fight against antibiotic resistant bacteria, Biomaterials Science accepted.
Publications
2019
1.Takahashi, H.,# Yumoto, K.,# Yasuhara, K., Nadres, E.T., Kikuchi, Y., Buttitta, L., Taichman, R.S. and Kuroda, K. (2019) Anticancer polymers designed for killing dormant prostate cancer cells. Scientific Reports 9: 1096. (#co-first author)
2018
1. Fukuzawa, T. and Kikuchi, Y.* (2018) Unusual light-reflecting pigment cells appear in the Xenopus neural tube culture system in the presence of guanosine. Tissue and Cell 54: 55-58.
2. Takayama, K., Muto, A. and Kikuchi, Y.* (2018) Leucine/glutamine and v-ATPase/lysosomal acidification via mTORC1activation are required for position-dependent regeneration. Scientific Reports 8: 8278.
3. Hozumi, S.*, Shirai, M., Wang, J., Aoki, S. and Kikuchi, Y.* (2018) The N-terminal domain of Gastrulation brain homeobox 2 (Gbx2) is required for iridophore specification in zebrafish. Biochemical and Biophysical Research Communications 502: 104-109.
4. Pauty, J., Usuba, R., Cheng, I.G., Hespel, L., Takahashi, H., Kato, K., Kobayashi, M., Nakajima, H., Lee, E., Yger, F., Soncin, F. and Matsunaga, Y.T. (2018) A vascular endothelial growth factor-dependent sprouting angiogenesis assay based on an in vitro human blood vessel model for the study of anti-angiogenic drugs. EBioMedicine 27: 225-236.
5. Lee, E., Takahashi, H., Pauty, J., Kobayashi, M., Kato, K., Kabara, M., Kawabe, J. and Matsunaga, Y.T. (2018) A 3D in vitro pericyte-supported microvessel model: visualisation and quantitative characterisation of multistep angiogenesis. Journal of Materials Chemistry B 6: 1085-1094.
6. Mikula, P., Mlnarikova, M., Takahashi, H., Babica, P., Kuroda, K., Blaha, L. and Sovadinova, I. (2018) Branched Poly(ethylene imine)s as Anti-algal and Anti-cyanobacterial Agents with Selective Flocculation Behavior to Cyanobacteria over Algae. Macromolecular Bioscience 18: 1800187.
2017
1. Hozumi S., Aoki S. and Kikuchi Y.* (2017) Nuclear movement regulated by non-Smad Nodal signaling via JNK is associated with Smad signal transduction during zebrafish endoderm specification. Development 144: 4015-4025.
2. Miles, L.B., Mizoguchi, T., Kikuchi, Y. and Verkade, H. (2017) A limited role for Planar Cell Polarity during early endoderm morphogenesis. Biology Open 6: 531-539.
3. Fujii M., Sakaguchi A., Kamata R., Nagao M., Kikuchi Y., Evans S.M., Yoshizumi M., Shimono A., Saga Y. and Kokubo H. (2017) Sfrp5 identifies murine cardiac progenitors for all myocardial structures except for the right ventricle. Nature Communications 8: 14664.
4. Iwasaka M., Tagawa K. and Kikuchi, Y. (2017) Magnetically tunable control of light reflection in an optical protein of Squid. AIP ADVANCES 7: 056722.
5. Shiomi T., Muto A., Hozumi S., Kimura H. and Kikuchi, Y.* (2017) Histone H3 lysine 27 trimethylation leads to loss of mesendodermal competence during gastrulation in zebrafish ectodermal cells. Zoological Science 34: 64-71.
6. Nadres, E.T.,# Takahashi, H.# and Kuroda, K. (2017) Radical-medicated end-group transformation of amphiphilic methacrylate random copolymers for modulation of antimicrobial and hemolytic activities. Journal of Polymer Science Part A: Polymer Chemistry 55: 304-312. (#co-first author)
7. Hong, S., Takahashi, H., Nadres, E.T., Mortazavian, H., Caputo, G.A., Younger, J.G. and Kuroda, K. (2017) A cationic amphiphilic random copolymer with pH-responsive activity against methicillin-resistant Staphylococcus aureus. PLoS ONE 12: e0169262.
8. Takahashi, H., Nadres, E.T. and Kuroda, K. (2017) Cationic amphiphilic polymers with antimicrobial activity for oral care applications: Eradication of S. mutans biofilm. Biomacromolecules 18(1): 257-265.
9. Takahashi, H., Kato, K., Ueyama, K., Kobayashi, M., Baik, G., Yukawa, Y., Suehiro, J. and Matsunaga, Y.T. (2017) Visualizing dynamics of angiogenic sprouting from a three-dimensional microvasculature model using stage-top optical coherence tomography. Scientific Reports 7: 42426.
10. Pauty, J., Usuba, R., Takahashi, H., Suehiro, J., Fujisawa, K., Yano, K., Nishizawa, T. and Matsunaga, Y.T. (2017) A vascular permeability assay using an in vitro human microvessel model mimicking the inflammatory condition. Nanotheranostics 1: 103-113.
11. Tachizawa, S.,# Takahashi, H.,# Kim, Y.J., Odawara, A., Pauty, J., Ikeuchi, Y., Suzuki, I., Kikuchi, A. and Matsunaga, Y.T. (2017) Bundle gel fibers with tunable microenvironment for in vitro neuron cell guiding. ACS Applied Materials and Interfaces 9(49): 43250-43257. (#co-first author)
12. Takahashi, H., Caputo, G.A., Vemparala, S. and Kuroda, K. (2017) Synthetic random copolymers as a molecular platform to mimic host-defense antimicrobial peptides. Bioconjugate Chemistry 28(5): 1340-1350.
2016
1. Nakahara Y, Muto A, Hirabayashi R., Sakuma T., Yamamoto T., Kume S. and Kikuchi, Y.* (2016) Temporal effects of Notch signaling and potential cooperation with multiple downstream effectors on adenohypophysis cell specification in zebrafish. Genes to Cells 21: 492–504.
2. Kim, Y.J., Yamamoto, S., Takahashi, H., Sasaki, N. and Matsunaga, Y.T. (2016) Multiwalled carbon nanotube reinforced biomimetic bundled gel fibres. Biomaterials Science 4: 1197-1201.
2015
1. Takahashi, H., Akiyoshi, K. and Kuroda, K. (2015) Affinity-mediated capture and release of amphiphilic copolymers for controlling antimicrobial activity. Chemical Communications 51: 12597-12600.
2. Fukuyama, Y., Yuki, Y., Katakai, Y., Harada, N., Takahashi, H., Takeda, S., Mejima, M., Joo, S.,Kurokawa, S., Sawada, S., Shibata, H., Park, E.J., Fujihashi, K., Briles, D.E.,Yasutomi, Y., Tsukada, H., Akiyoshi, K. and Kiyono, H. (2015) Nanogel-based pneumococcal surface protein A nasal vaccine induces microRNA-associated Th17 cell responses with neutralizing antibodies against Streptococcus pneumoniae in macaques. Mucosal Immunology 8: 1144-1153.
2014
1. Muto, A., Ikeda, S., Lopez-Burks, M.E., Kikuchi, Y.,* Calof, A.L.,* Lander, A.D.* and Schilling, T.F.* (2014) Nipbl and mediator cooperatively regulate gene expression to control limb development. PLoS Genetics 10(9): e1004671.
2. Hirose, K., Shiomi, T., Hozumi, S. and Kikuchi, Y.* (2014) Mechanistic target of rapamycin complex 1 signaling regulates cell proliferation, cell survival, and differentiation in regenerating zebrafish fins. BMC Developmental Biology 14(1): 42.
3. Shimoda N, Hirose K, Kaneto R, Izawa T, Yokoi H, Hashimoto N. and Kikuchi, Y. (2014) No Evidence for AID/MBD4-Coupled DNA Demethylation in Zebrafish Embryos. PLoS One 9(12): e114816.
4. Takayama, K., Shimoda, N., Takanaga, S., Hozumi, S. and Kikuchi, Y.* (2014) Expression patterns of dnmt3aa, dnmt3ab, and dnmt4 during development and fin regeneration in zebrafish. Gene Expression Patterns 14: 105-110.
5. Shimoda, N., Izawa, T., Yoshizawa, A., Yokoi, H., Kikuchi, Y. and Hashimoto, N. (2014) Decrease in cytosine methylation at CpG island shores and increase in DNA fragmentation during zebrafish aging. Age 36: 103-115.
2013
1. Hirose, K., Shimoda, N. and Kikuchi, Y.* (2013) Transient reduction of 5-methylcytosine and 5-hydroxymethylcytosine is associated with active DNA demethylation during regeneration of zebrafish fin. Epigenetics 9: 899-906.
2. Hirabayashi, R., Hozumi, S., Higashijima, S. and Kikuchi, Y.* (2013) Ddx46 Is Required for Multi-Lineage Differentiation of Hematopoietic Stem Cells in Zebrafish. Stem Cells and Development 22: 2532-2542.
3. Morimoto, N., Hirano, S., Takahashi, H., Loethen, S., Thompson, D.H. and Akiyoshi, K. (2013) Self-assembled pH-sensitive cholesteryl pullulan nanogel as a protein delivery vehicle. Biomacromolecules 14: 56-63.
4. Kong, I.G., Sato, A., Yuki, Y., Nochi, T., Takahashi, H., Sawada, S.,Mejima, M., Kurokawa, S., Okada, K., Sato, S., Briles, D.E., Kunisawa, J.,Inoue, Y., Yamamoto, M., Akiyoshi, K. and Kiyono, H. (2013) Nanogel-based PspA intranasal vaccine prevents invasive disease and nasal colonization by Streptococcus pneumoniae. Infection and Immunity 81: 1625-1634.
5. Tsukao, H., Kokubo, K., Takahashi, H., Nagasato, M., Endo, T.,Iizuka, N., Shinbo, T., Hirose, M. and Kobayashi, H. (2013) Activation of platelets upon contact with a vitamin E-coated/non-coated surface. Journal of Artificial Organs 16: 193-205.
6.Takahashi, H., Tahara, Y., Sawada, S. and Akiyoshi, K. (2013) Cationic amphiphilic polysaccharide nanoballs: protein stabilization and intracellular delivery by nano-encapsulation. Biomaterials Science 1(8): 842-849.
7. Takeda, S., Takahashi, H., Sawada, S., Sasaki, Y. and Akiyoshi, K. (2013) Amphiphilic nanogel of enzymatically synthesized glycogen as an artificial molecular chaperone for effective protein refolding. RSC Advences 3(48): 25716-25718.
8. Yuki, Y., Nochi, T., Kong, I.G., Takahashi, H., Sawada, S., Akiyoshi, K. and Kiyono, H. (2013) Nanogel-based antigen-delivery system for nasal vaccines. Biotechnology and Genetic Engineering Reviews 29(1): 61-72.
9.Takahashi, H., Palermo, E.F., Yasuhara, K., Caputo, G.A. and Kuroda, K. (2013) Molecular design, structures, and activity of antimicrobial peptide-mimetic polymers. Macromolecular Bioscience 13(10): 1285-1299.
2012
1. Hozumi, S., Hirabayashi, R., Yoshizawa, A., Ogata, M., Ishitani, T., Tsutsumi, M., Kuroiwa, A., Itoh, M. and Kikuchi, Y.* (2012) DEAD-Box Protein Ddx46 Is Required for the Development of the Digestive Organs and Brain in Zebrafish. PLoS One 7(3): e33675.
2011
1. Yoshizawa, A., Nakahara, Y., Izawa, T., Ishitani, T., Tsutsumi, M., Kuroiwa, A., Itoh, M. and Kikuchi, Y.*(2011) Zebrafish Dmrta2 regulates neurogenesis in the telencephalon. Genes to Cells 16: 1097-109.
2. Hirose, K., Shimoda, N. and Kikuchi, Y.* (2011) Expression patterns of lgr4 and lgr6 during zebrafish development. Gene Expression Patterns 11: 378-383.
3.Takahashi, H., Sawada, S. and Akiyoshi, K. (2011) Amphiphilic polysaccharide nanoballs: a new building block for nanogel biomedical engineering and artificial chaperones. ACS nano 5(1): 337-345.
4. Sasaki, Y., Iida, D., Takahashi, H., Sawada, S. and Akiyoshi, K. (2011) Artificial chaperone polysaccharide nanogels for protein delivery: a thermodynamic study of protein-nanogel interactions using fluorescence correlation spectroscopy. Current Drug Discovery Technologies 8(4): 308-313.
2010
1. Nochi, T., Yuki, Y., Takahashi, H., Sawada, S., Mejima, M., Kohda, T., Harada, N., Kong, I.G., Sato, A., Kataoka, N., Tokuhara, D., Kurokawa, S., Takahashi, Y., Tsukada, H., Kozaki, S., Akiyoshi, K. and Kiyono, H. (2010) Nanogel antigenic protein-delivery system for adjuvant-free intranasal vaccines. Nature materials 9: 572-578.
2009
1. Kinkel, M.D., Sefton, E.M., Kikuchi, Y., Mizoguchi, T., Ward, A.B. and Prince, V.E. (2009) Cyp26 enzymes function in endoderm to regulate pancreatic field size. Proc. Natl. Acad. Sci. USA 106: 7864-7869.
2. Boridy, S., Takahashi, H., Akiyoshi, K. and Maysinger, D. (2009) The binding of pullulan modified cholesteryl nanogels to Aβ oligomers and their suppression of cytotoxicity. Biomaterials 30: 5583-5591.
2008
1. Mizoguchi, T., Verkade, H., Heath, J., Kuroiwa, A. and Kikuchi, Y.* (2008) Sdf1/Cxcr4 signaling controls the dorsal migration of endodermal cells during zebrafish gastrulation. Development 135: 2521-2529.
2. Iizuka, M., Tomita, M., Shimizu, K., Kikuchi, Y. and Yoshizato, K. (2008) Translational enhancement of recombinant protein synthesis in transgenic silkworms by a 5’-untranslated region of polyhedrin gene of Bombyx mori Nucleopolyhedrovirus. Journal of Bioscience and Bioengineering 105: 595-603.
3. Motoi, N., Suzuki, K., Hirota, R., Johnson, P., Oofusa, K., Kikuchi, Y. and Yoshizato, K. (2008) Identification and characterization of nucleoplasmin 3 as a histone- binding protein in embryonic stem cells. Development Growth & Differentiation 50: 307-320.
4. Nomiyama, H., Hieshima, K., Osada, N., Kato-Unoki, Y., Otsuka-Ono, K., Takegawa, S., Izawa, T., Yoshizawa, A., Kikuchi, Y., Tanase, S., Miura, R.,Kusuda, J., Nakao, M. and Yoshie, O. (2008) Extensive expansion and diversification of the chemokine gene family in zebrafish: identification of a novel chemokine subfamily CX. BMC Genomics 9: 222.
5. Wilkins, S.J., Yoong, S., Verkade, H., Mizoguchi, T., Plowman, S.J., Hancock, J.F., Kikuchi, Y., Heath, J.K. and Perkins, A.C. (2008) Mtx2 directs zebrafish morphogenetic movements during epiboly by regulating microfilament formation. Developmental Biology 314: 12-22.
2007
1.Nikaido, M., Doi, K., Shimizu, T., Hibi, M., Kikuchi, Y. and Yamasu, K. (2007) Initial specification of the epibranchial placode in zebrafish embryos depends on the fibroblast growth factor signal. Developmental Dynamics 236: 564-571.
2006
1. Mizoguchi, T., Izawa, T., Kuroiwa, A. and Kikuchi, Y.* (2006) Fgf signaling negatively regulates Nodal-dependent endoderm induction in zebrafish. Developmental Biology 300: 612-622.
2. Sakaguchi, T., Kikuchi, Y., Kuroiwa, A., Takeda, H. and Stainier, D.Y.R. (2006) The yolk syncytial layer regulates myocardial migration by influencing extracellular matrix assembly in zebrafish. Development 133: 4063-4072.
2005
1. Bjornson, C.R.R., Griffin, K.J.P., Farr III, G.H., Terashima, A., Himeda, C., Kikuchi, Y. and Kimelman, D. (2005) Eomesodermin is a localized maternal determinant required for endoderm induction in zebrafish. Developmental Cell 9: 523-533.
2004
1. Kikuchi, Y.,* Verkade, H., Reiter, J.F., Kim, C.-H., Chitnis, A.B., Kuroiwa, A. and Stainier, D.Y.R.* (2004) Notch signaling can regulate endoderm formation in zebrafish. Developmental Dynamics 229: 756-762.
2. Reim, G., Mizoguchi, T., Stainier, D.Y.R., Kikuchi, Y. and Brand, M. (2004) The POU domain protein spg (Pou2/Oct4) is essential for endoderm formation in cooperation with the HMG domain protein Casanova. Developmental Cell 6: 91-101.
2001
1. Mizuno, T., Kawasaki, M., Nakahira, M., Kagamiyama, H., Kikuchi, Y.,Okamoto, H., Mori, K. and Yoshihara, Y. (2001) Molecular diversity in zebrafish NCAM family: three members with different VASE usage and distinct localization. Molecular and Cellular Neuroscience 18: 119-130.
2. Kikuchi, Y., Agathon, A., Alexander, J., Thisse, C., Waldron, S., Yelon, D., Thisse, B. and Stainier, D.Y.R. (2001) casanova encodes a novel Sox-related protein necessary and sufficient for early endoderm formation in zebrafish. Genes & Development 15: 1493-1505.
3. Segawa, H., Miyashita, T., Hirate, Y., Higashijima, S., Chino, N., Uyemura, K., Kikuchi, Y. and Okamoto, H. (2001) Functional repression of Islet-2 by disruption of complex with Ldb impairs pripheral axonal outgrowth in embryonic zebrafish. Neuron 30: 423-436.
4. Reiter, J.F., Kikuchi, Y. and Stainier, D.Y.R. (2001) Multiple roles for Gata5 in zebrafish endoderm formation. Development 128: 125-135.
2000
1. Kikuchi, Y., Trinh, L.A., Reiter, J.F., Alexander, J., Yelon, D. and Stainier, D.Y.R. (2000) The zebrafish bonnie and clyde gene encodes a Mix family homeodomain protein that regulates the generation of endodermal precursors. Genes & Development 14: 1279-1289.
2. Saito, T., Hascilowicz, T., Ohkido, I., Kikuchi, Y., Okamoto, H.,Hayashi, S., Murakami, Y. and Matsufuji, S. (2000) Two zebrafish (Danio rerio) antizymes with different expression and activities. Biochemical Journal 345: 99-106.
1999
1. Mieda, M., Kikuchi, Y., Hirate, Y., Aoki, M. and Okamoto, H. (1999) Compartmentalized expression of zebrafish ten-m3 and ten-m4, homologues of the Drosophila tenm/odd Oz gene, in the central nervous system. Mechanisms of Development 87: 223-227.
1997
1. Kikuchi, Y., Segawa, H., Tokumoto, M., Tsubokawa, T., Hotta, Y., Uyemura, K. and Okamoto, H. (1997) Ocular and cerebellar defects in zebrafish induced by overexpression of the LIM domains of the Islet-3 LIM/homeodomain protein. Neuron 18: 369-382.
1996
1. Shimoda, N., Chevrette, M., Ekker, M., Kikuchi, Y., Hotta, Y. and Okamoto, H. (1996) Mermaid, A family of short interspersed repetitive element, is useful for the zebrafish genome mapping. Biochemical and Biophysical Research Communications 220: 233-237.
2. Shimoda, N., Chevrette, M., Ekker, M., Kikuchi, Y., Hotta, Y. and Okamoto, H. (1996) Mermaid : A family of short interspersed repetitive elements widespread in vertebrates. Biochemical and Biophysical Research Communications 220: 226-232.